Michigan molecular interactions r2: from interacting proteins to pathways.

TitleMichigan molecular interactions r2: from interacting proteins to pathways.
Publication TypeJournal Article
Year of Publication2009
AuthorsV Tarcea, Glenn, Weymouth Terry, Ade Alex, Bookvich Aaron, Gao Jing, Mahavisno Vasudeva, Wright Zach, Chapman Adriane, Jayapandian Magesh, Ozg├╝r Arzucan, Tian Yuanyuan, Cavalcoli Jim, Mirel Barbara, Patel Jignesh, Radev Dragomir, Athey Brian, States David, and Jagadish H V.
JournalNucleic Acids Res
Volume37
IssueDatabase issue
PaginationD642-6
Date Published2009 Jan
ISSN1362-4962
KeywordsComputer Graphics, Databases, Protein, Protein Interaction Mapping, Proteins, User-Computer Interface
Abstract

Molecular interaction data exists in a number of repositories, each with its own data format, molecule identifier and information coverage. Michigan molecular interactions (MiMI) assists scientists searching through this profusion of molecular interaction data. The original release of MiMI gathered data from well-known protein interaction databases, and deep merged this information while keeping track of provenance. Based on the feedback received from users, MiMI has been completely redesigned. This article describes the resulting MiMI Release 2 (MiMIr2). New functionality includes extension from proteins to genes and to pathways; identification of highlighted sentences in source publications; seamless two-way linkage with Cytoscape; query facilities based on MeSH/GO terms and other concepts; approximate graph matching to find relevant pathways; support for querying in bulk; and a user focus-group driven interface design. MiMI is part of the NIH's; National Center for Integrative Biomedical Informatics (NCIBI) and is publicly available at: http://mimi.ncibi.org.

DOI10.1093/nar/gkn722
Alternate JournalNucleic Acids Res.
PubMed ID18978014
PubMed Central IDPMC2686565
Grant ListR01 LM008106 / LM / NLM NIH HHS / United States
U54 DA021519 / DA / NIDA NIH HHS / United States