Needs for an expanded ontology-based classification of adverse drug reactions and related mechanisms.

TitleNeeds for an expanded ontology-based classification of adverse drug reactions and related mechanisms.
Publication TypeJournal Article
Year of Publication2012
AuthorsZhichkin, P E., Athey B D., Avigan M I., and Abernethy D R.
JournalClin Pharmacol Ther
Volume91
Issue6
Pagination963-5
Date Published2012 Jun
ISSN1532-6535
KeywordsBayes Theorem, Classification, Clinical Trials as Topic, Computational Biology, Databases, Factual, Drug-Related Side Effects and Adverse Reactions, Humans, Models, Organizational, Pharmacovigilance, Public Health, Terminology as Topic
Abstract

The growing significance of bioinformatics and systems biology in drug safety research requires a system of adverse-event classification that goes beyond a simple vocabulary. This opinion piece outlines the need for development of an ontology-based framework of describing adverse drug reactions (ADRs) and describes the potential applications for such a framework.

DOI10.1038/clpt.2012.41
Alternate JournalClin. Pharmacol. Ther.
PubMed ID22609907